Solid State NMR workshop

Posted on Monday June 27, 2016 by kristaps
InnovaBalt 283
in collaboration with Centre de RMN à Très Hauts Champs de Lyon Lecturers:
Dr. Guido Pintacuda
Dr. Sachin Chaudhari
Dr. Jan Stanek
Dr. Diane Cala		 283

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11th-14th July 2016, Latvian Institute of Organic Synthesis

Monday, 11th July Practicals at the spectrometer
10-12 Practical on spectrometer setup (all lecturers)
12-13 Lunch
13-17 Practical on experiment setup (all lecturers)
Tuesday, 12th July Lectures for general audience
9:15-10:30 Solid state NMR principles, applications in chemistry and biology (Guido Pintacuda)
10.30-10:45 Coffee break
10.45-12.00 Solid state NMR of materials (Sachin Chaudhari)
12.00-12:45 Lunch
12.45-13.30 Successful writing of ERC grant application (Guido Pintacuda)
Wednesday, 13th July Lectures for expert audience
10-12 Protein sample preparation for solid state NMR (Diane Cala)
12-13 Lunch
13-15 Solid state NMR of proteins (Guido Pintacuda and Jan Stanek)
Thursday, 14th July Practicals on data processing and analysis
10-12 Processing of NMR spectra (all lecturers)
12-13 Lunch
13-17 Analysis of protein solid state NMR spectra (all lecturers)

Download SMALL NMR data

Download NMR data (alternative)

Download CARA

Download loaded CARA file

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Lectures by professor Michael Sattler (Helmholtz Zentrum München and Technische Universität München)

Posted on Friday September 11, 2015 by kristaps
InnovaBalt 283

22nd September 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 NMR studies of protein ligand interactions
10.50-11.35 Structure based drug design
11.35-12.00 Coffee break
12.00-12.45 Isotope labeling of proteins by expression in E.coli
12.45-13.15 Discussions and snacks
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We are on the back cover of ChemBioChem

Posted on Monday August 10, 2015 by kristaps

Back Cover: Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains (ChemBioChem 12/2015) Link to article

IMG_2093
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Seminar Molecular modeling for drug design

Posted on Monday May 25, 2015 by kristaps
InnovaBalt 283

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5th June 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 Amedeo Caflisch (University of Zürich, Zürich, Switzerland)
Molecular dynamics in drug design
10.50-11.35 Christoph Rademacher (Max Planck Institute of Colloids and Interfaces, Berlin, Germany)
Fragment-based ligand design of C-type lectin ligands
11.35-12.00 Discussions and snacks
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Seminar by Professor Volker Dötsch (Goethe University Frankfurt)

Posted on Monday April 6, 2015 by kristaps
InnovaBalt 283

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21st April 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 Combination of cell-free synthesis and NMR spectroscopy for the structure determination of membrane proteins
10.50-11.35 In-cell NMR studies for the investigation of the behavior of macromolecules in living cells
11.35-12.00 Coffee break
12.00-12.45 The tales of p63: investigation of the structure and function of p63, using a wide variety of techniques
12.45-13.15 Discussions and snacks
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800 MHz NMR Spectrometer Inauguration

Posted on Sunday March 9, 2014 by kristaps
IMGP9134Official ribbon cutting by the Institute’s director prof. Ivars Kalviņš with assistance from prof. Jānis Stradiņš, founder of the Laboratory of Physical Organic Chemistry IMG_2787Speakers of the Inauguration Symposium: (from left) Guido Pintacuda, Martin Billeter, Gottfried Otting, Edvards Liepiņš, Kristaps Jaudzems, Henrik Biverstål and Ēriks Kupče

TV footage from the ribbon cutting ceremony

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800 MHz NMR Spectrometer Inauguration Symposium

Posted on Saturday January 11, 2014 by kristaps
InnovaBalt 283

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27th January 2014, Conference Hall, Latvian Institute of Organic Synthesis

9.30-10.00 Registration and coffee
10.00-10.15 Welcome remarks
10.15-10.50 Gottfried Otting (Australian National University, Canberra, Australia)
Lanthanides for structural biology by NMR
10.50-11.25 Guido Pintacuda (Center for High Field NMR, Lyon, France)
High-resolution 1H-detected solid-state NMR: from microcrystalline proteins to large assemblies
11.25-11.40 Coffee break
11.40-12.15 Martin Billeter (University of Gothenburg, Gothenburg, Sweden)
Intercalation of large molecules into DNA: intermediates and mechanisms
12.15-12.50 Ēriks Kupče (Bruker Biospin, Coventry, UK)
New ways to record multi-dimensional NMR spectra
12.50-13.45 Lunch
13.45-14.10 Henrik Biverstål (Karolinska Institute, Stockholm, Sweden)
Biophysical studies of the BRICHOS-domain
14.10-14.35 Kristaps Jaudzems (Latvian Institute of Organic Synthesis)
Mechanism of spider silk formation by NMR
14.35-14.50 Concluding remarks
15.00-15.20 Formal opening of the 800 MHz NMR spectrometer facility
15.20-16.00 Reception
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The new 800 MHz NMR spectrometer has arrived

Posted on Tuesday September 24, 2013 by kristaps
IMG_2093 IMG_2097
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(Latviešu) LZP tematisko pētījumu projektu konkurss – kas īsti slēpjas aiz skaisti skanošā “starptautiskā izvērtējuma”?

Posted on Tuesday March 12, 2013 by kristaps

Sorry, this entry is only available in Latviešu.

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New equipment for protein – small molecule interaction studies

Posted on Tuesday February 5, 2013 by kristaps

Our lab has recently obtained state-of-the-art equipment for studying biomolecular interactions based on surface plasmon resonance (SPR, Biacore T200 instrument) and isothermal titration calorimetry (ITC, MicroCal iTC200 instrument) techniques. Both instruments will facilitate our drug discovery efforts, in particular, the Biacore T200 will be used for fragment screening and the MicroCal iTC200 will aid in structure-based design. Importantly, these methods are very much complementary to NMR and in many cases provide a (better) alternative to tasks such as fragment library screening and determination of binding affinities and thermodynamics.

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