Seminar Molecular modeling for drug design

InnovaBalt 283

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5th June 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 Amedeo Caflisch (University of Zürich, Zürich, Switzerland)
Molecular dynamics in drug design
10.50-11.35 Christoph Rademacher (Max Planck Institute of Colloids and Interfaces, Berlin, Germany)
Fragment-based ligand design of C-type lectin ligands
11.35-12.00 Discussions and snacks
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Seminar by Professor Volker Dötsch (Goethe University Frankfurt)

InnovaBalt 283

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21st April 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 Combination of cell-free synthesis and NMR spectroscopy for the structure determination of membrane proteins
10.50-11.35 In-cell NMR studies for the investigation of the behavior of macromolecules in living cells
11.35-12.00 Coffee break
12.00-12.45 The tales of p63: investigation of the structure and function of p63, using a wide variety of techniques
12.45-13.15 Discussions and snacks
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800 MHz NMR Spectrometer Inauguration

IMGP9134Official ribbon cutting by the Institute’s director prof. Ivars Kalviņš with assistance from prof. Jānis Stradiņš, founder of the Laboratory of Physical Organic Chemistry IMG_2787Speakers of the Inauguration Symposium: (from left) Guido Pintacuda, Martin Billeter, Gottfried Otting, Edvards Liepiņš, Kristaps Jaudzems, Henrik Biverstål and Ēriks Kupče

TV footage from the ribbon cutting ceremony

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800 MHz NMR Spectrometer Inauguration Symposium

InnovaBalt 283

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27th January 2014, Conference Hall, Latvian Institute of Organic Synthesis

9.30-10.00 Registration and coffee
10.00-10.15 Welcome remarks
10.15-10.50 Gottfried Otting (Australian National University, Canberra, Australia)
Lanthanides for structural biology by NMR
10.50-11.25 Guido Pintacuda (Center for High Field NMR, Lyon, France)
High-resolution 1H-detected solid-state NMR: from microcrystalline proteins to large assemblies
11.25-11.40 Coffee break
11.40-12.15 Martin Billeter (University of Gothenburg, Gothenburg, Sweden)
Intercalation of large molecules into DNA: intermediates and mechanisms
12.15-12.50 Ēriks Kupče (Bruker Biospin, Coventry, UK)
New ways to record multi-dimensional NMR spectra
12.50-13.45 Lunch
13.45-14.10 Henrik Biverstål (Karolinska Institute, Stockholm, Sweden)
Biophysical studies of the BRICHOS-domain
14.10-14.35 Kristaps Jaudzems (Latvian Institute of Organic Synthesis)
Mechanism of spider silk formation by NMR
14.35-14.50 Concluding remarks
15.00-15.20 Formal opening of the 800 MHz NMR spectrometer facility
15.20-16.00 Reception
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The new 800 MHz NMR spectrometer has arrived

IMG_2093 IMG_2097
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(Latviešu) LZP tematisko pētījumu projektu konkurss – kas īsti slēpjas aiz skaisti skanošā “starptautiskā izvērtējuma”?

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New equipment for protein – small molecule interaction studies

Our lab has recently obtained state-of-the-art equipment for studying biomolecular interactions based on surface plasmon resonance (SPR, Biacore T200 instrument) and isothermal titration calorimetry (ITC, MicroCal iTC200 instrument) techniques. Both instruments will facilitate our drug discovery efforts, in particular, the Biacore T200 will be used for fragment screening and the MicroCal iTC200 will aid in structure-based design. Importantly, these methods are very much complementary to NMR and in many cases provide a (better) alternative to tasks such as fragment library screening and determination of binding affinities and thermodynamics.

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(Latviešu) Publicē mūsu pētījumus par zirnekļu tīkla zīda veidošanās mehānismu

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(Latviešu) EAST-NMR 2. Jauno pētnieku konference

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(Latviešu) Kristaps atkal piedalās LR1 raidījumā “Zināmais nezināmajā”

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