Award ceremony for 2017 achievements in Latvian science

On February 16, 2018 the Latvian Academy of Sciences (LZA) and the Science Foundation held the award ceremony of the most significant science achievements in Latvia in 2017. One of the prizes was awarded to Kristaps Jaudzems and Martins Otikovs for “Determination of the molecular mechanism of spider silk formation and assessment of the degree of biomimicry of artificial spider silk spinning”.

Video by Zinātnes fonds.

Kristaps Jaudzems receives the diploma from Inese Čakstiņa. All award winners.

Photos by Jānis Brencis.

Posted in Uncategorized | Leave a comment

Our study earns recognition as 2017 achievement in Latvian science

Latvian Academy of Sciences has announced 12 most important achievements of 2017 in Latvian science. Among them is our study on the determination of the molecular mechanism of spider silk formation and assessment of the degree of biomimicry of artificial spider silk spinning, which was carried out in collaboration with Karolinska Institute in Sweden (Karolinska Institutet) and Institute of Analytical Sciences in France (Institut des Sciences Analytiques).
Spider silk is a high-performance material with perspective applications in a range of areas from biomedicine to construction. The spiders spin their web from silk fibres that are made of proteins. Thus far, the process of the spider silk fibre formation was incompletely understood, making it difficult to develop effective technologies for the production of artificial spider silk. Researchers at LIOS have studied the process of native spider silk spinning and established the mechanism of molecular transformations that ensure controlled conversion of soluble silk proteins into solid fibres. The acquired knowledge was used to assess the degree of biomimicry of state-of-the-art approaches for artificial spider silk spinning, allowing to propose improved technologies for the production artificial spider silk.
The achievement was featured in the newspaper Latvijas Avīze, as well as on national TV (LTV Rīta Panorāma) and on skaties.lv.

Posted in Uncategorized | Leave a comment

(Latviešu) Angewandte Chemie publicē mūsu pētījumus par mākslīgo zirnekļu zīdu

Sorry, this entry is only available in Latviešu.

Posted in Uncategorized | Leave a comment

Solid State NMR workshop

InnovaBalt 283
in collaboration with Centre de RMN à Très Hauts Champs de Lyon Lecturers:
Dr. Guido Pintacuda
Dr. Sachin Chaudhari
Dr. Jan Stanek
Dr. Diane Cala
283

REGISTER HERE

11th-14th July 2016, Latvian Institute of Organic Synthesis

Monday, 11th July Practicals at the spectrometer
10-12 Practical on spectrometer setup (all lecturers)
12-13 Lunch
13-17 Practical on experiment setup (all lecturers)
Tuesday, 12th July Lectures for general audience
9:15-10:30 Solid state NMR principles, applications in chemistry and biology (Guido Pintacuda)
10.30-10:45 Coffee break
10.45-12.00 Solid state NMR of materials (Sachin Chaudhari)
12.00-12:45 Lunch
12.45-13.30 Successful writing of ERC grant application (Guido Pintacuda)
Wednesday, 13th July Lectures for expert audience
10-12 Protein sample preparation for solid state NMR (Diane Cala)
12-13 Lunch
13-15 Solid state NMR of proteins (Guido Pintacuda and Jan Stanek)
Thursday, 14th July Practicals on data processing and analysis
10-12 Processing of NMR spectra (all lecturers)
12-13 Lunch
13-17 Analysis of protein solid state NMR spectra (all lecturers)

Download SMALL NMR data

Download NMR data (alternative)

Download CARA

Download loaded CARA file

Posted in Uncategorized | Leave a comment

Lectures by professor Michael Sattler (Helmholtz Zentrum München and Technische Universität München)

InnovaBalt 283

22nd September 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 NMR studies of protein ligand interactions
10.50-11.35 Structure based drug design
11.35-12.00 Coffee break
12.00-12.45 Isotope labeling of proteins by expression in E.coli
12.45-13.15 Discussions and snacks
Posted in Uncategorized | Leave a comment

We are on the back cover of ChemBioChem

Back Cover: Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains (ChemBioChem 12/2015) Link to article

IMG_2093
Posted in Uncategorized | Leave a comment

Seminar Molecular modeling for drug design

InnovaBalt 283

REGISTER HERE

5th June 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 Amedeo Caflisch (University of Zürich, Zürich, Switzerland)
Molecular dynamics in drug design
10.50-11.35 Christoph Rademacher (Max Planck Institute of Colloids and Interfaces, Berlin, Germany)
Fragment-based ligand design of C-type lectin ligands
11.35-12.00 Discussions and snacks
Posted in Uncategorized | Leave a comment

Seminar by Professor Volker Dötsch (Goethe University Frankfurt)

InnovaBalt 283

REGISTER HERE

21st April 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 Combination of cell-free synthesis and NMR spectroscopy for the structure determination of membrane proteins
10.50-11.35 In-cell NMR studies for the investigation of the behavior of macromolecules in living cells
11.35-12.00 Coffee break
12.00-12.45 The tales of p63: investigation of the structure and function of p63, using a wide variety of techniques
12.45-13.15 Discussions and snacks
Posted in Uncategorized | Leave a comment

800 MHz NMR Spectrometer Inauguration

IMGP9134Official ribbon cutting by the Institute’s director prof. Ivars Kalviņš with assistance from prof. Jānis Stradiņš, founder of the Laboratory of Physical Organic Chemistry IMG_2787Speakers of the Inauguration Symposium: (from left) Guido Pintacuda, Martin Billeter, Gottfried Otting, Edvards Liepiņš, Kristaps Jaudzems, Henrik Biverstål and Ēriks Kupče

TV footage from the ribbon cutting ceremony

Posted in Uncategorized | Leave a comment

800 MHz NMR Spectrometer Inauguration Symposium

InnovaBalt 283

REGISTER HERE

27th January 2014, Conference Hall, Latvian Institute of Organic Synthesis

9.30-10.00 Registration and coffee
10.00-10.15 Welcome remarks
10.15-10.50 Gottfried Otting (Australian National University, Canberra, Australia)
Lanthanides for structural biology by NMR
10.50-11.25 Guido Pintacuda (Center for High Field NMR, Lyon, France)
High-resolution 1H-detected solid-state NMR: from microcrystalline proteins to large assemblies
11.25-11.40 Coffee break
11.40-12.15 Martin Billeter (University of Gothenburg, Gothenburg, Sweden)
Intercalation of large molecules into DNA: intermediates and mechanisms
12.15-12.50 Ēriks Kupče (Bruker Biospin, Coventry, UK)
New ways to record multi-dimensional NMR spectra
12.50-13.45 Lunch
13.45-14.10 Henrik Biverstål (Karolinska Institute, Stockholm, Sweden)
Biophysical studies of the BRICHOS-domain
14.10-14.35 Kristaps Jaudzems (Latvian Institute of Organic Synthesis)
Mechanism of spider silk formation by NMR
14.35-14.50 Concluding remarks
15.00-15.20 Formal opening of the 800 MHz NMR spectrometer facility
15.20-16.00 Reception
Posted in Uncategorized | Leave a comment